BDBM23163 CHEMBL114606::FTY720-phosphate, rac-2::{2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propoxy}phosphonic acid
SMILES CCCCCCCCc1ccc(CCC(N)(CO)COP(O)(O)=O)cc1
InChI Key InChIKey=LRFKWQGGENFBFO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 23163
Affinity DataKi: 4.10nM ΔG°: -10.6kcal/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 0.280nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Activity at human S1P1 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 9.10nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells preincubated for 2 hrs before IP1 addition by IP1-HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMpH: 7.4Assay Description:Agonism of human S1P-1 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Activity at human S1P1 receptor expressed in HEK293T cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0140nMAssay Description:Displacement of 33-P-S1P from from human S1P receptor expressed in CHO cell membranes after 50 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.00500nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by HTRF analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 0.00560nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells assessed as ERK phosphorylation after 7 mins by alphaLISAMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0700nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells co-expressing GFP assessed as cellular internalization after 45 mins by Hoechst assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.377nMAssay Description:Agonist activity at human S1P1 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.350nMAssay Description:Agonist activity at human S1P1 receptor expressed in human Chem1 cells assessed as intracellular calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Effective concentration against sphingosine-1-phosphate receptor 1 determined by a [c-35S]-GTP binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.40nMAssay Description:Agonist activity at S1P1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0200nMAssay Description:Agonist activity at human recombinant S1P1 expressed in CHO cells assessed as stimulation of ERK phosphorylation incubated for 7 mins by microplate r...More data for this Ligand-Target Pair
Affinity DataIC50: 0.00800nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Agonist activity at recombinant human S1P1 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0700nMAssay Description:Agonist activity at human recombinant C-terminal GFP-fused S1P1 expressed in CHO cells assessed as induction of receptor internalization incubated fo...More data for this Ligand-Target Pair
Affinity DataEC50: 1.70nMAssay Description:Agonist activity at S1P1 receptor (unknown origin) expressed in PathHunter CHO-K1 EDG1 beta-arrestin cells assessed as induction of beta-arrestin 2 r...More data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Agonist activity at S1P1 receptor (unknown origin) expressed in PathHunter HEK 293 EDG1 Total GPCR Internalization cells assessed as receptor interna...More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 1 expressed on CHO cell membranesMore data for this Ligand-Target Pair